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KMID : 0371620020170020205
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Journal of Wonkwang Medical Science
2002 Volume.17 No. 2 p.205 ~ p.208
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A case of propylthiouracil-induced severe hepatitis
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Im Chong-Ju
Sim Mi-Ryeong
Lee Myeung-Su
Kim Tae-Hyeon
Oh Seok-Kyu
Ahn Seon-Ho
Park Moo-Rim
Kim Nam-Ho
Park Byoung-Hyun
Cho Chung-Gu
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Abstract
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Propylthiouracil is widely used to treat patients with hyperthyroidism. This drug has been associated with severe hepatotoxicity rarely. We presented the case of jaundice and profound liver dysfunction from a 23-year old woman treated with propylthiouracil for hyperthyroidism. Viral, metabolic, and autoimmune liver disease could be excluded and liver biopsy revealed a pattern of acute hepatitis. After discontinuing the drug, there was a progressive resolution of hepatic symptoms and decrease in biochemical data of the liver. Despite propylthiouracil induced hepatitis in rare case, patients receiving propylthiouracil are exposed to develope severe hepatotoxicity. Therefore it might be advisable to monitor level of the transaminase on regular base from patients receiving propylthiouracil.
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KEYWORD
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Propylthiouracil, hepatotoxicity
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